Conserved 3′ stem-loop structures enable comprehensive analysis of bacterial transcription termination in metagenomes

Yunfan Jin, Jiyun Cui, Rulong Liu, Hongli Ma, Xiaomin Xu, Shufang Wu, Fei Gan, Zhi John Lu, Zhenjiang Zech Xu
July 2026
Cite DOI URL

Abstract

Bacterial transcription termination is a critical yet underexplored layer of gene regulation in microbial ecosystems. Existing computational tools, however, primarily focus on predicting transcript 3′ ends generated by Rho-independent terminators (RITs) in a few model species, leaving gaps in understanding those generated by Rho-dependent terminators (RDTs) and their diversity across Bacteria.

Type
Journal article
Publication
Microbiome
Bacterial Terminator Transcription Termination Transcription Unit Prediction
Rulong Liu
Rulong Liu
M.S. student
Zhenjiang Zech Xu
Zhenjiang Zech Xu
Professor

My research interests include microbiome, (meta)genomics and machine learning.