Systematic Evaluation of Antimicrobial Food Preservatives on Glucose Metabolism and Gut Microbiota in Healthy Mice
摘要
Certain antimicrobial preservatives (APs) have been shown to perturb gut microbiota. So far, it is not yet fully known that whether similar effects are observable for a more diverse set of APs. It also remains elusive if biogenic APs are superior to synthetic APs in terms of safety. To help fill these knowledge gaps, the effects of eleven commonly used synthetic and biogenic APs on the gut microbiota and glucose metabolism were evaluated in the wild-type healthy mice. Here, we found that APs induced glucose intolerance and perturbed gut microbiota, irrespective of their origin. In addition, biogenic APs are not always safer than synthetic ones. The biogenic AP nisin unexpectedly induced the most significant effects, which might be partially mediated by glucagon-like peptide 1 related glucoregulatory hormones secretion perturbation.
Ping Li
Ph.D. student
Ming Li
Ph.D. student
Tao Wu
M.S. student
Ying Song
M.S. student
Yan Li
M.S. student
Xiaochang Huang
Lecturer
Hui Lu
postdoctoral fellow
